When Simmons and Holden are trying to figure out how to save May, they paraphrase Sherlock Holmes' famous quip "When you eliminate the impossible, whatever remains, however improbable, must be the truth."
This takes place after Captain America: Civil War (2016). The new director mentions the Sokovia Accords and Steve Rogers being on the run.
This is the first episode with Parminder Nagra. She and Ming-Na Wen were co-stars of the 10th season of ER (1994).
"Uprising" debuted at New York Comic Con, before airing on ABC on October 11, 2016.
This was watched by 4.89 million viewers within a week.