Cases of the week include (Frank) prison riots due to a social experiment the mayor is trying, (Jamie) an 18 year old that overdoses, and (Danny) a wife and mother found murdered in her home.
Danny and Baez investigate the murder of a single mother whose ex-husband has a history of violence. Also, Frank deals with the fallout when Mayor Dutton (Lorraine Bracco) eliminates solitary confinement in prisons, and Jamie's efforts to save a young woman who overdosed on drugs has unexpected consequences.