In the United States, "Amor, Amor, Amor" peaked at number ten on the Hot Latin Songs chart for the week ending December 2, 2017.
The video generated 8 million views in its first three days.
Discussing working with Lopez, Wisin stated: "It's always an honor to work with talented people who are visionary and want to keep growing. I respect her very much in many aspects. At the beginning of my career she was one of the big artists that gave me an opportunity and believed in what we did."
Mike Wass of Idolator described the artwork featuring Lopez and Wisin as a "sexy, neon-drenched affair".
"Amor, Amor, Amor" is a reggae-ton song that fuses dance and urban music styles.