The song was released by Top Dawg Entertainment, Aftermath Entertainment, and Interscope Records on February 2, 2018, as the album's third single.
It serves as the second overall collaboration between the two artists.
"Pray for Me" is composed in the key of E minor.
Alex Robert Ross of Noisey praised the song, calling it "short, punchy, and self-lacerating."
Canada CHR/Top 40 (Billboard) peak position 1, 2018.