Charlie's return from holiday in positive mood receives several knocks thanks to a teenager dying of an overdose, two brothers with a secret, an old neighbour with Crohn's disease and David getting overinvolved with an attempted murderer.
David has to deal with a visit from Rosalene, a journalist and a former nurse with a burned eye. Teddy gets involved with two brothers who were in a car crash. Dylan asks Marcus for help with dwindling resources.
Teddy tries to help a teenager trapped in a mineshaft, Iain and Faith disagree over how to deal with a drunk single mother, Stevie treats cat-related injuries and Robyn is bombarded with opinions on the surrogacy.
Dylan is shaken by an injury to a friend, Stevie gets involved with two teenaged runaways and Robyn helps a man with learning difficulties missing his old carer.
The department is full of opposing football fans, leaving Stevie trying to protect a father and daughter and save a police officer who was stabbed. David's resolve is threatened when Rob's mum is brought in.
Sah is taken hostage by an injured cyclist while dealing with their dad having another stroke. Dylan copes with a terminally ill elderly woman, a male patient with an embarrassing problem and a board room ambush by Marcus.
Faith and Iain try to get to the bottom of things when Keith Hutton is stabbed, Robyn worries about Marty and Adi's relationship while helping a woman who swallowed an engagement ring and Dylan and Marcus clash over trolleys.
Robyn is rushed into resus with a pulmonary embolism, the discovery Jonty's life has fallen to pieces affects Stevie as she treats a distressed pregnant woman and an RTC casualty, and Marty meets a man bossed about by his young daughter.
Paige gets caught up in a van driving into a crowd outside a church, Stevie faces a dilemma when a patient keeps his medical condition secret from his wife and Marty tries to return Adi's belongings.
Stevie runs into trouble while helping a young woman in a controlling relationship, Jan and Sah try to help a family trapped in an unsafe car, and Marty and Paul meet a confused woman from a theatrical background.
Faith is invited out by Iain but distracted when Elsie comes in with an overdose, Paige's desire to impress Stevie causes her to go too far treating a bodybuilder, and Jan is frustrated by self-inflicted injuries and a careless driver.
A four day period sees Jan, Sah, Iain and Teddy tackle a number of cases including a drunk who can't find his girlfriend, a young woman who stops breathing after an allergic reaction and a woman gone into labour on a bus.
Dylan finds his old mentor among the casualties brought in from a fire at a retirement home, Rash discovers Ashok's hiding something after Mona turns up with an injured hand and Paige pushes for answers with a teenager with vague symptoms.
Blackmail from Jonty distracts Stevie from helping a man who believes he is the Son of God, Rash balances two patients with caring for Ashok, and Paul and Robyn are reunited with an old classmate.
Jan and Sah help with the sinking of a boat full of migrants, Dylan and Faith try to deal with a rash of poisoning from Willco care home and Stevie learns she is receiving bad reviews while helping a cancer survivor.
Ethan gets a lesson about fatherhood when treating both Ash and a young acid attack victim, Jacob is reminded of his abuse by an old colleague and a support group friend, and Paige investigate a young man apparently beaten up.
Rash is confronted by Ashok's deterioration when he causes a car accident with a young couple, Marcus uses Stevie's treatment of a young dancer to cause trouble between her and Faith, and Robyn finds out what Paul has been getting up to.
Jacob tries to help a trapped jogger who has fallen into a ravine, Dylan and David investigate another elderly patient and Paige's tiredness hampers her investigation of a patient's condition.
With patients coming in from a derailed train, locum consultant Max Christie gets involved with a girl footballer having a miscarriage, Stevie neglects an unco-operative patient and Robyn has a realisation about Paul while treating a baby.
Stevie gets insight into Marcus when his ex-girlfriend is admitted to a mental ward, Max and Faith help a teenage girl having a series of accidents and Rash is determined to get Ashok into a home after treating a worn-out social worker.
Ashok stabs a carer, giving Dylan another piece of evidence. Stevie befriends a cyber security expert while making a complaint against Marcus. Jacob tries to find out why a patient's notes don't match.
Robyn is asked to work late on her last day and becomes concerned with a new mum. Faith and Iain work together to help a father and daughter impaled at a fairground. Jacob loses his temper with a teenager who was treated for leukaemia.
Robyn is rushed into hospital and Jacob faces criticism for delaying the ambulance. Faith learns the significance of Elsie's injuries. David tries to help an elderly patient and Marty is unable to reassure a woman facing cancer tests.
Dylan is determined to get the right result when Supriya is stabbed by Roy Welch. Faith helps a bride with an allergic reaction and an unrepentant drug user. Jacob loses his temper with a patient who is a spiritualist.
The truth about Faith's addiction is revealed as she deals with painful memories of Angus, blackmail from Kerrel and looking after a girl whose mother is missing following a car accident.
New clinical nurse manager Donna has four new staff. Jodie Whyte helps Max with a man who was beaten up, Cam Mickelthwaite nurses a terminal heart patient and Jacob's first shift as a paramedic involves a woman whose husband has died.
Jan is frustrated when a drunken homeless man turns out to be her ex-husband Gethin. Jacob is unhappy about having to leave an old man being harassed by teens. Ryan tries to prove his worth with a young woman with hearing loss.
Teddy and Sah get into trouble after attending an altercation at Krish's shop. Rida defends a pregnant Downs Syndrome woman. Faith clashes with a mother who gives her teenage son vapes and alcohol.
Stevie suffers a crisis of confidence after losing a teenager stabbed in the neck. Jacob is incensed by two youths involved in a bull stunt. Gethin gets into trouble helping a drowning teenager. Dylan and Donna disagree over a patient.
Dylan, Donna, Ryan and Jodie are trapped in resus when a patient turns out to be collecting grenades. Max and Faith treat a boy hit by a car and Cam consoles a patient who fears dying of a heart attack.
Jodie is in trouble after being spiked on a night out, Faith is told her rape case is being dropped and takes it out on Cam while treating a flight attendant, and Ryan fails to impress Max while diagnosing a student.
Jacob has a bad day after failing to stop a man falling from a roof, Faith's withdrawals hamper her helping a snake bite victim and Jan tries to cheer up Gethin with a trip to the seaside.
Iain has flashbacks while attending a car crash caused by a young man jumping from a bridge, Faith feels guilty when a girl she dismissed comes back in beaten up and Max, Jodie and Rida treat a young man with an overprotective father.
Max and Jodie treat sisters suspected of people smuggling as rumours spread about them. Jacob is uncomfortable collecting a patient from where Billie works and Jan is disconcerted while helping an elderly terminally ill woman.
Knowledge of Gethin's suicide plan leaves Jan determined to deliver a donor heart involved in a motorway crash. Jodie learns of her mistake with Freya Hall but is distracted by a stabbing patient. Faith comforts a patient's partner.
Faith is left with explaining to do after rushing one of Luka's friends in with a suspected overdose, Stevie and Ryan try to help an overworked ballerina and a meeting with a troubled teenager causes Jacob to have a think about Billie.
Jodie is offered a farewell do after saving a boy's life, which sees several staff caught up in an explosion. Iain's pondering over Faith is interrupted when a schoolgirl he treats turns out to be racist. Cam tries to prove his worth.
With commentary by real-life NHS workers, the whole team work to save an injured motorcyclist. Stevie has to break bad news to some parents and Ryan treats an elderly birthday girl.
Donna is left exhausted after a shift helping a non-English speaker whose wife dies. Faith dodges questions from Iain while treating a teenager with a secret. Jan reconnects with Ffion after one of her colleagues has an accident.
Donna lies about the accident when the other party try to make a bogus insurance claim. Jan has differing experiences with a self-harmer and a gang of youths. An old man with a dog gives Ryan a way to build bridges with Cameron.
Max and Jodie have concerns about a mother and son involved in a car accident, Paige enlists Teddy's help to reunite a dying patient with her dog and Jan has a mixed encounter with the daughter of an old patient.
Stevie deals with a casualty from an acid attack. Faith uses an elderly patient to get round Max's new counter-signing drug system. Donna finds Ashley in a poor state with a self-inflicted injury. Iain and Jacob have trouble with addicts.
Donna's guilt over Ashley increases while treating a teenage overdose victim. Jan and Ffion help a neighbour give birth. Rida witnesses Rash flirting with a patient. Faith has to keep up the cancer lie with Stevie.