During a visit to New Orleans Alex is attracted to an old college friend and is bitten by a vampire. When she returns to Legacy house the college friend and the vampire follow her and Alex fights the urge to make her first kill.
Kristin Adams from the Boston Legacy House comes to San Francisco following a series of church burnings. She hopes to save her younger brother from the cult responsible for the fires.
Kristin takes off to find her long-missing father after receiving a mysterious ancient map, but Derek and Nick are suspicious and follow her to Istanbul.
When unknown forces besiege the Legacy House while Kristin and Rachel are away, Derek goes over his recollections of past enemies to try to identify who might be returning.