While both "Slither" (2006) and "Night of the Creeps" (1986) are horror-comedy movies with similar creature elements, they have distinct storylines and different styles of humor.
Slither (2006) focuses on an alien parasite that takes over a small town, turning its residents into zombie-like creatures. The film has a darker tone and features more gore and body horror elements than "Night of the Creeps." The humor in "Slither" is also more explicit and raunchy.
Night of the Creeps (1986) on the other hand, follows a similar premise with an alien slug that turns its victims into zombie-like creatures. However, the film has a more lighthearted and campy tone, with a focus on 1950s-style horror and sci-fi tropes. The humor in "Night of the Creeps" is more subtle and relies on parodying classic horror movie clichés.
So while both movies share some similarities, they have distinct differences in their style, tone, and humor.